Endocrine Abstracts

Introduction: Kisspeptin is a 54-amino acid peptide, which comprise a diverse group of peptides with many different functions related to energy metabolism and reproduction, pubertal development. It activates GPR54 receptor. Subcutaneous administration of kisspeptin-54 to women with regular menstrual cycles results in an increase in LH and FSH. All these findings show that the GPR54 system may play a role in the function of the hypothalamic–pituitary–gonadal axis. PCO...

Introduction: Majority of polycystic ovary syndrome (PCOS) women are anovulatory, overweight/obese and insulin resistant. Kisspeptins are the endogenous ligands for GPR54 highly expressed in pancreas. Some studies showed that kisspeptins may play in the regulation of islet function and they stimulate insulin secretion from mouse and human islets. Adipose tissue acts as an endocrine organ and its function may be regulated by kisspeptins. We designed this study based on that obe...